A Search For Genetic Modifiers Responsible For Congenital Heart Disease Variability In The Presence Of Nkx2-5 Haploinsufficiency

نویسندگان

  • Julia Brandeis
  • Winston Honold
  • James Cheverud
  • Robert Mecham
  • Kelle Moley
  • David Ornitz
چکیده

i-ii Acknowledgments iii List of Tables and Figures v 1. Chapter 1: Introduction and Background 1-14 1.1. Literature Review 1-5 1.2. Background Data 6-10 1.3. Conclusion 11 1.4. Reference List 12-14 2. Chapter 2: Heterogeneity of Genetic Modifiers Endures Normal Cardiac Development 15-47 2.1. Abstract 15 2.2. Introduction 16-18 2.3. Methods 19-20 2.4. Results 21-29 2.5. Discussion 30-33 2.6. Reference List 34-36 2.7. Figures and Tables 37-47 3. Chapter 3: Characterization of Modifiers of Congenital Heart Disease in Nkx2-5 risk Model 48-82 3.1. Abstract 48-49 3.2. Introduction 49-51 3.3. Methods 51-56 3.4. Results 56-61 3.5. Discussion 62-66 3.6. Reference List 67-69 3.7. Figures and Tables 70-82 4. Chapter 4: Conclusion and Future Directions 83-90 4.1. Genomic Mapping of Genetic Modifiers 83-86 4.2. Further Examination of Maternal Age Effect 86-88 4.3. Reference List 89-90

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تاریخ انتشار 2017